Evidence map›Paper›PMID 42808099›Full record

ArticleFrontiers in toxicology2026

ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male mice.

Omar A Yanouri, Adam J Schuller, Savannah M Rocha, Aidan M Briggs, Paul A Martinez, Elizabeth Fernandez, Randy Strong, Xueshu Li, Hans-Joachim Lehmler, Jonathan A Doorn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Omar A YanouriDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Adam J SchullerDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Savannah M RochaDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Aidan M BriggsDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States.
Paul A MartinezDepartment of Pharmacology, Barshop Institute, University of Texas San Antonio Health Sciences Center, San Antonio, TX, United States.
Elizabeth FernandezGeriatric Research, Educational and Clinical Center (GRECC), South Texas Healthcare System, San Antonio, TX, United States.
Randy StrongDepartment of Pharmacology, Barshop Institute, University of Texas San Antonio Health Sciences Center, San Antonio, TX, United States.
Xueshu LiDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, United States.
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, United States.
Jonathan A DoornDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.
Ronald B TjalkensDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons diseaseR35ES035043 · NIEHS · COLORADO STATE UNIVERSITY · PI RONALD TJALKENS · 2023 to 2026
$4.4M
Pesticide-Mediated Generation of a Toxic Neurotransmitter MetaboliteR01ES029035 · NIEHS · UNIVERSITY OF IOWA · PI DOORN, JONATHAN A · 2018 to 2022
$1.9M
BLRD VA I01 BX001641NIA NIH HHS P30 AG013319NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R01 ES029035NIEHS NIH HHS R35 ES035043
6 · The paper itself

Abstract

The etiology of Parkinson's disease (PD) is associated with exposure to environmental contaminants, including the organochlorine pesticide dieldrin. This is thought to occur through induction of oxidative damage and dysregulation of dopamine homeostasis via impairment of aldehyde dehydrogenase (ALDH) enzymes, resulting in neuronal stress that may contribute to glial-mediated neurotoxicity. We postulated that sub-chronic murine dieldrin exposure would induce PD-relevant histopathologic changes in the substantia nigra (SN) which would be exacerbated in ALDH-deficient mice. To test this hypothesis, six-month-old wildtype and Aldh1a1

Indexed as

dieldrinmicroglianeurodegenerationorganochlorineParkinson’s diseasepesticide

Identifiers

PMID42808099
PMCPMC13619124

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.