Evidence map›Paper›PMID 42809011›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Inter-eye comparison of corneal stiffness parameters in primary open-angle glaucoma patients with unilateral damage.

Yunxiao Sun, Ruiqi Pang, Kai Cao, Ningli Wang, Jing Li

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yunxiao SunBeijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Ruiqi PangBeijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Kai CaoBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ningli WangBeijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Jing LiBeijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China. crystal_lijing@ccmu.edu.cn.

Funding

Beijing Hospitals Youth Talent Program 2021-YJJ-ZZL-036General Program of National Natural Science Foundation of China 82471057
6 · The paper itself

Abstract

purposeTo investigate inter-eye differences in corneal biomechanical properties as assessed by Corvis ST among primary open-angle glaucoma (POAG) patients with unilateral damage.

designprospective cross-sectional study.

methodsThis study included 240 eyes from 120 treatment-naïve patients with POAG, of which 60 were classified as normal-tension glaucoma (NTG) and 60 as high-tension glaucoma (HTG). Paired eyes were categorized into glaucomatous eyes and clinically unaffected fellow eyes according to ophthalmic examination. Ocular parameters, including corneal biomechanical properties, were compared between paired eyes within each group (POAG group, NTG and HTG subgroup). The generalized estimation equation (GEE) models with a binary logistic link were employed to examine the association between ocular parameters and the presence of glaucoma.

resultsEyes with POAG had significantly higher biomechanically corrected intraocular pressure (bIOP; p = 0.007), more negative spherical equivalent (SE; p = 0.018), longer axial length (AL; p = 0.006), and thinner central corneal thickness (CCT; p = 0.007) than unaffected fellow eyes. Binocular comparison results differed across subgroups. NTG eyes had significantly thinner CCT (p = 0.015) and lower stiffness parameter at first applanation (SP-A1; p = 0.013) than unaffected fellow eyes. In contrast, HTG eyes showed significantly higher bIOP (p = 0.002), more negative SE (p = 0.047), and longer AL (p = 0.009) compared to controls. Multivariable GEE analysis demonstrated that higher baseline bIOP was significantly associated with the presence of both POAG (odds ratio, 1.111; p = 0.009) and HTG (odds ratio, 1.225; p = 0.002). In the NTG subgroup, lower SP-A1 was the only factor significantly correlated with the presence of glaucoma (odds ratio, 0.985; p = 0.035).

conclusionsIncreased baseline bIOP was correlated with unilateral glaucomatous damage in patients with POAG and HTG. However, a lower corneal stiffness parameter was associated with glaucomatous eyes in NTG. This finding suggests that eyes with a more deformable cornea are vulnerable to glaucomatous damage, even when the IOP is within the normal range.

Indexed as

Corneal stiffness parameterCorvis STInter-eye comparisonPrimary open-angle glaucomaUnilateral glaucomatous damage

Identifiers

PMID42809011

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.