ArticleProceedings of the National Academy of Sciences of the United States of America2026
Distribution and voltage dependence of ion channels shape single-neuron computations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Voltage-gated ion channels do not distribute evenly in the plasma membrane of a neuron; they localize to distinct domains where they govern the excitability of the cell and the computations it performs. Informed by electron microscopic reconstructions, models of morphologically realistic neurons offer the opportunity to study these computations, but they lack constraints on the subcellular localizations and functional properties of voltage-gated channels. Here, we address this problem in
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