Evidence map›Paper›PMID 42810392›Full record

ArticleAging cell2026

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies.

Eliano Dos Santos, Marie Blickling, Fiona C Leiper, John-Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R Wilson, Steven J Gamblin, Bénédicte Chazaud, Giovanna Lollo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eliano Dos SantosMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0000-0001-7091-3647
Marie BlicklingCECAD Research Cluster, University of Cologne, Köln, Germany.ORCID https://orcid.org/0000-0003-0770-3449
Fiona C LeiperMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0000-0001-6681-681X
John-Patrick AlaoSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-1728-8560
Claudia LennickeMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0009-0008-5304-5145
Andrea FoleyMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0000-0003-0596-5533
Jon R WilsonThe Francis Crick Institute, London, UK.ORCID https://orcid.org/0000-0002-5157-5432
Steven J GamblinThe Francis Crick Institute, London, UK.ORCID https://orcid.org/0000-0001-5331-639X
Bénédicte ChazaudInstitut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle, Université Claude Bernard Lyon 1, Inserm U1315, CNRS UMR 5261, Université de Lyon, Lyon, France.ORCID https://orcid.org/0000-0002-1262-502X
Giovanna LolloLaboratoire d'Automatique, de Génie des Procédés et de Génie Pharmaceutique, Université Claude Bernard Lyon 1, CNRS UMR 5007, Villeurbanne, France.ORCID https://orcid.org/0000-0001-7030-3056
Rémi MounierInstitut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle, Université Claude Bernard Lyon 1, Inserm U1315, CNRS UMR 5261, Université de Lyon, Lyon, France.ORCID https://orcid.org/0000-0003-3464-3322
Gaëtan JubanInstitut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle, Université Claude Bernard Lyon 1, Inserm U1315, CNRS UMR 5261, Université de Lyon, Lyon, France.ORCID https://orcid.org/0000-0002-5845-9223
Charalampos RallisSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0002-4390-0266
David CarlingMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0000-0002-2316-1830
Filipe CabreiroInstitute of Clinical Sciences, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-3696-4843
Helena M CocheméMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID https://orcid.org/0000-0001-8637-0042

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Medical Research Council MC-M302-M3450NIH HHS P40 OD010440NIH HHS P40 OD010949
6 · The paper itself

Abstract

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis and plays a central role in metabolic health and disease. AMPK has also been implicated in ageing; however, most in vivo drug studies rely on the use of indirect activators, such as metformin, which have complex modes-of-action, therefore making conclusions on the specific role of AMPK more challenging. Here, we demonstrate that direct activation of AMPK with the compound 991 extends lifespan in Drosophila melanogaster, Caenorhabditis elegans and Schizosaccharomyces pombe. In mice, 991 treatment induces a pro-longevity proteomic profile, highlighting the potential for translation to mammals. Overall, our study provides important proof-of-principle for AMPK as a pharmacological target with longevity benefits.

Indexed as

AMP-Activated Protein KinasesCaenorhabditis elegansDrosophila melanogasterLongevitySaccharomyces cerevisiaeSchizosaccharomycesAnimalsEnzyme ActivationMiceAMP-Activated Protein KinasesageingAMPKCaenorhabditis elegansDrosophila melanogasterenergy metabolismlifespanpharmacologySchizosaccharomyces pombe

Identifiers

PMID42810392
PMCPMC13623501

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.