Evidence map›Paper›PMID 42810981›Full record

ArticlePhysiological reports2026

Persistent endothelial dysfunction is associated with exercise intolerance in adults despite preserved myocardial work 3 years after SARS-CoV-2 infection.

Carla Cristina de Araújo Alves, Cássia da Luz Goulart, Luciana D'Ávila, Beatriz Helena Ernesto de Souza Silva, Igor Machado Alves, Brena Vitória Souza Aguiar, Claudia Conde, Ricardo Stein, Gerson Cipriano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carla Cristina de Araújo AlvesLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0000-0003-0986-6399
Cássia da Luz GoulartLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0000-0001-8731-689X
Luciana D'ÁvilaLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0000-0002-0953-1321
Beatriz Helena Ernesto de Souza SilvaLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0009-0000-9293-4430
Igor Machado AlvesLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0009-0009-3149-377X
Brena Vitória Souza AguiarLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0009-0007-1072-196X
Claudia CondeLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0009-0000-1650-2927
Ricardo SteinInternal Medicine Department, Federal University of Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0003-2357-5176
Gerson CiprianoLaboratory of Clinical Exercise Physiology, FCE, University of Brasília (UnB), Brasília, DF, Brazil.ORCID https://orcid.org/0000-0001-9560-6520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long COVID is frequently associated with persistent exercise intolerance, although the relative contributions of peripheral vascular dysfunction and myocardial function remain unclear. We investigated whether persistent endothelial dysfunction and altered myocardial work (MW) contribute to exercise intolerance approximately 3 years after SARS-CoV-2 infection. This case-control study included adults with Long COVID (n = 10) and controls (n = 11) who underwent cardiopulmonary exercise testing (CPET), transthoracic echocardiography with global longitudinal strain (GLS) and MW analysis, and brachial artery flow-mediated dilation (FMD) with hyperemic shear assessment. Compared with controls, Long COVID participants exhibited lower peak V̇O

Indexed as

COVID-19Endothelium, VascularExercise ToleranceAdultBrachial ArteryCase-Control StudiesEchocardiographyExercise TestFemaleGlobal Longitudinal StrainHumansMaleMiddle AgedOxygen ConsumptionPost-Acute COVID-19 SyndromeVasodilationbrachial flow‐mediated dilationexercise toleranceLong COVIDmyocardial workvascular endothelium

Identifiers

PMID42810981
PMCPMC13623666

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.