Evidence map›Paper›PMID 42810983›Full record

ArticlePhysiological reports2026

Quantifying the effects of hemoglobin saturation on plasma strong ion difference during blood oxygenation and decarboxylation.

Lorenzo Giosa, Martin Krbec, Jakub Halamík, Adrian Bolnberger, Mattia Busana, Serena Brusatori, Tue Diemer, Søren R Kristensen, Micah L A Heldeweg, Francesco Zadek and 2 more

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorenzo GiosaDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-0145-5125
Martin KrbecDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Jakub HalamíkDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.ORCID https://orcid.org/0009-0007-3340-1993
Adrian BolnbergerDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Mattia BusanaDepartment of Anesthesiology, University Medical Center of Göttingen, Göttingen, Germany.
Serena BrusatoriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Tue DiemerDepartment of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark.
Søren R KristensenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Micah L A HeldewegDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Francesco ZadekDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Stephen E ReesInstitute for Health Science and Technology, Aalborg University, Aalborg, Denmark.
František DuškaDepartment of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.

Funding

Agentura Pro Zdravotnický Výzkum České Republiky (AZV ČR) NW26-01-00360Grantová Agentura, Univerzita Karlova (GA UK) PRIMUS/26/MED/009
6 · The paper itself

Abstract

The strong ion difference (SID) is assessed to interpret acid-base disorders, yet measured plasma values are influenced by electrolyte redistribution across compartments. Current models focus on pH-dependent plasma-erythrocyte shifts. Here, we aim to quantify the effects of hemoglobin oxygen saturation (sO

Indexed as

HemoglobinsOxygenOxygen SaturationAcid-Base EquilibriumDecarboxylationHumansHydrogen-Ion ConcentrationHemoglobinsOxygenalbuminhemoglobinnon‐carbonic whole‐blood buffer poweroxygen saturationplasma strong ion difference

Identifiers

PMID42810983
PMCPMC13623668

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.