Evidence map›Paper›PMID 42811296›Full record

ArticleMolecular medicine (Cambridge, Mass.)2026

HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity.

Ya Huang, Qingcheng Xu, Meijuan Zhu, Yawei Shen, Xianwen Zhang

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Article in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ya Huang *Department of Oncology, Northern Jiangsu People's Hospital, 98 Nantong West Rd, Yangzhou, 225001, China.
Qingcheng Xu *Department of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
Meijuan ZhuDepartment of Oncology, Northern Jiangsu People's Hospital, 98 Nantong West Rd, Yangzhou, 225001, China.
Yawei ShenDepartment of Oncology, Northern Jiangsu People's Hospital, 98 Nantong West Rd, Yangzhou, 225001, China.
Xianwen ZhangDepartment of Oncology, Northern Jiangsu People's Hospital, 98 Nantong West Rd, Yangzhou, 225001, China. XianwenZhang1@163.com.

Funding

General project of Yangzhou Basic Research Program Joint Special Health ProjectYangzhou soft science Research Project No. 2024110
6 · The paper itself

Abstract

backgroundDespite the promise of immune checkpoint inhibitors (ICIs) for gastric cancer (GC) treatment, limited cytotoxic T cell infiltration remains a major barrier to therapeutic efficacy. This study investigates whether targeting HEAT repeat containing 1 (HEATR1) can induce immunogenic PANoptosis to enhance anti-tumor immunity.

methodsBioinformatics analysis of TCGA-STAD cohort, syngeneic mouse models, and patient-derived organoids (PDOs) were employed to assess HEATR1 function. Mechanistic studies examined STAT1/IRF1 signaling, PANoptosis markers, and dendritic cell (DC) activation. Therapeutic efficacy was evaluated in combination with anti-PD1 immunotherapy.

resultsHEATR1 expression inversely correlated with CD8

conclusionsHEATR1 deficiency enhances GC cell sensitivity to IFN-γ-mediated PANoptosis via STAT1/IRF1 pathway activation, creating an immunogenic tumor microenvironment that potentiates ICI efficacy. These findings identify HEATR1 as a promising therapeutic target for improving GC immunotherapy outcomes.

Indexed as

Stomach NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsDisease Models, AnimalFemaleHumansImmunotherapyInterferon Regulatory Factor-1MiceOrganoidsSignal TransductionSTAT1 Transcription FactorInterferon Regulatory Factor-1STAT1 Transcription FactorCD8+ T cellsDendritic cellsGastric cancerImmunogenic cell deathPANoptosisPatient-derived organoids

Identifiers

PMID42811296
PMCPMC13625226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.