Comparative diagnostic performance of coronary CT angiography and invasive coronary angiography in patients with suspected coronary artery disease.

Arya Farzollahzadeh, Mohammad-Javad Shahsavari, Mehrnaz Mashoufi, Faraz Malek Bagali, Soheila Refahi

Abstract readComparative Study

In one paragraph

Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Arya FarzollahzadehStudent Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Mohammad-Javad ShahsavariMedical Student, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Mehrnaz MashoufiDepartment of Health Information Management, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Faraz Malek BagaliStudent Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Soheila RefahiDepartment of Medical Physics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. s.refahi@arums.ac.ir.

Funding

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6 · The paper itself

Abstract

backgroundCoronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although invasive coronary angiography (ICA) is the reference standard for diagnosing CAD, coronary computed tomography angiography (CCTA) has emerged as a valuable non-invasive alternative. This study compared the diagnostic performance of CCTA with ICA in patients with suspected CAD.

methodsIn this descriptive cross-sectional study, 155 patients who underwent both CCTA and ICA were included. Coronary stenosis was classified as mild (1-49%), moderate (50-69%), or severe (≥ 70%). ICA served as the reference standard. Diagnostic performance was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy.

resultsThe mean age of the patients was 57.3 ± 9.15 years, and 67.7% were male. CCTA demonstrated a sensitivity of 96.0%, specificity of 33.3%, PPV of 85.7%, NPV of 66.7%, and an overall accuracy of 83.9%. The LAD showed the highest vessel-based sensitivity (87%), whereas the LCX had the lowest (60%). CCTA correctly identified all cases of moderate stenosis and detected 69% of severe stenoses.

conclusionCCTA demonstrated high sensitivity for detecting CAD but relatively limited specificity in this high-risk population. These findings support its role as a useful non-invasive diagnostic tool, while ICA remains the reference standard for confirming coronary artery stenosis.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsSensitivity and SpecificityCoronary artery diseaseCoronary artery stenosisCoronary computed tomography angiographyDiagnostic accuracyInvasive coronary angiographySensitivitySpecificity

Identifiers

PMID42811303

DOI10.1186/s12880-026-02785-3

PMCPMC13625413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.