Evidence map›Paper›PMID 42811342›Full record

ArticleFluids and barriers of the CNS2026

Integrative multi-omics profiling reveals an association between lipid metabolism dysregulation and bortezomib-induced cerebral hemorrhage in zebrafish.

Yulian Li, Si Dong, Hao Cheng, Yunyun Du, Shanshan Zhu, Fasheng Liu, Yongliang Zheng, Ting Ding, Wenfeng He, Xiaoping Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yulian LiDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Si DongDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Hao ChengDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Yunyun DuDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Shanshan ZhuDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Fasheng LiuDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Yongliang ZhengDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Ting DingDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China.
Wenfeng HeDepartment of Medical Genetics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Xiaoping WangComprehensive Teaching and Research Office, Ji'an College, Ji'an, Jiangxi Province, 343000, China.
Zigang CaoDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China. zigangcao@163.com.
Junquan ZengDepartment of Hematology, The Affiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Jinggangshan University, Ji'an, Jiangxi Province, 343000, China. commandozjq@163.com.ORCID https://orcid.org/0000-0001-9823-8284

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bortezomib (BTZ), a first-generation proteasome inhibitor, serves as a cornerstone chemotherapeutic agent for Multiple Myeloma (MM), with its clinical application in oncology expanding rapidly in recent years. Using vascular-specific transgenic zebrafish models, we systematically evaluated BTZ-induced toxicity at 4-5 mg/L gradient concentrations and its underlying molecular mechanisms. We found 72-hour BTZ exposure triggered significant intracerebral hemorrhage in zebrafish larvae with concentration-dependent severity, accompanied by cerebrovascular disruption, tight junction gene downregulation, lipid metabolism disorder, ROS accumulation and antioxidant enzyme response, and abnormal nitric oxide activation. This study first reveals that BTZ-induced intracerebral hemorrhage is closely associated with lipid metabolism dysregulation, highlighting lipid disturbance as a potential contributor to cerebrovascular injury.

Indexed as

Antineoplastic AgentsBortezomibCerebral HemorrhageLipid MetabolismProteasome InhibitorsAnimalsAnimals, Genetically ModifiedDisease Models, AnimalMultiomicsZebrafishAntineoplastic AgentsBortezomibProteasome InhibitorsBlood-brain barrierBortezomib (BTZ)HemorrhageLipid metabolismNeurovascular toxicityVascular

Identifiers

PMID42811342
PMCPMC13625479

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.