Evidence map›Paper›PMID 42811620›Full record

ReviewChemMedChem2026

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins.

Álvaro de la Cruz-Potenciano, Miguel Maldonado, María-José Camarasa, Sonia de Castro

Abstract readReview
In one paragraph

Review in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Álvaro de la Cruz-PotencianoInstituto de Química Médica y Biomedicina (IQMB-CSIC), Madrid, Spain.ORCID https://orcid.org/0009-0006-9891-8996
Miguel MaldonadoInstituto de Química Médica y Biomedicina (IQMB-CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0002-2166-7088
María-José CamarasaInstituto de Química Médica y Biomedicina (IQMB-CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0002-4978-6468
Sonia de CastroInstituto de Química Médica y Biomedicina (IQMB-CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0002-3838-6856

Funding

Comunidad de Madrid BIPPED-2 S2010/BMD-2457Comunidad de Madrid BIPPED-CM S-BIO-0214-2006Comunidad de Madrid PLATESA2-CM S2018/BAA-4370Consejo Superior de Investigaciones Científicas PIE 201280E093Consejo Superior de Investigaciones Científicas PIE-201980E028Consejo Superior de Investigaciones Científicas PIE201980E028MICIU PID2022-136307OB-C21Ministerio de Ciencia e Innovación PID2019-104070RB-C21Ministerio de Ciencia e Innovación SAF2015-64629-C2-1RMinisterio de Economía y Competitividad SAF2009-13914-C02Ministerio de Economía y Competitividad SAF2012-39760-C02
6 · The paper itself

Abstract

Human coronaviruses include both endemic respiratory pathogens and highly pathogenic viruses with pandemic potential, underscoring the need for antiviral agents with activity beyond single viral species. This review focuses on selected, representative antiviral inhibitors directed against viral proteins of human coronaviruses. Accordingly, the review examines representative inhibitors targeting viral proteins essential for coronavirus infection and propagation. The discussion includes inhibitors acting at different functional levels of the viral life cycle, such as entry, genome replication, RNA processing and particle assembly, and reflects the range of molecular entities reported to date. By organizing known inhibitors according to their viral protein targets, this review provides an integrated overview of current antiviral candidates and illustrates the central role of viral proteins as points of intervention. Overall, the review aims to consolidate existing knowledge on antiviral inhibitors across human coronaviruses, offering a coherent framework for appreciating their scope and diversity.

Indexed as

Antiviral AgentsCoronavirusViral ProteinsHumansAntiviral AgentsViral Proteinsbroad‐spectrum antiviralscoronavirus inhibition strategieshuman coronavirusessmall‐molecule inhibitorsviral protein targets

Identifiers

PMID42811620
PMCPMC13624369

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.