Evidence map›Paper›PMID 42812143›Full record

SynthesisPediatric diabetes2026

Efficacy and safety of hybrid closed-loop systems in children aged < 7 years with type 1 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Tingting Zhang, Na Wang, Bo Wang, Menghao Wang, Jia Zhang

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingting ZhangDepartment of Pediatric, Suqian First Hospital, Suqian, Jiangsu 223800, China.
Na WangDepartment of Pediatric, Suqian First Hospital, Suqian, Jiangsu 223800, China.
Bo WangDepartment of Pediatric, Suqian First Hospital, Suqian, Jiangsu 223800, China.
Menghao WangDepartment of Pediatric, Suqian First Hospital, Suqian, Jiangsu 223800, China.
Jia ZhangDepartment of Pediatric, Suqian First Hospital, Suqian, Jiangsu 223800, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the clinical efficacy and safety of hybrid closed-loop systems for glycemic control in children aged < 7 years with Type 1 diabetes. Relevant studies published up to July 30, 2025 were electronically retrieved from the PubMed, Cochrane Library, Embase, and Web of Science databases. Two investigators independently screened the literature, extracted valid data, and assessed the risk of bias of included studies, with a meta-analysis conducted via RevMan 5.4 software. Three randomized controlled trials, with 274 children enrolled, were incorporated into the analysis. The results indicated that 3 months of using the hybrid closed-loop system significantly increased the percentage of time in range (mean difference [MD] = 9.95%, 95% confidence interval [CI] [7.8, 12.09],

Indexed as

Diabetes Mellitus, Type 1Glycemic ControlHypoglycemic AgentsInsulinInsulin Infusion SystemsBlood GlucoseChildChild, PreschoolGlycated HemoglobinHumansHypoglycemiaRandomized Controlled Trials as TopicTreatment OutcomeBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinArtificial pancreasChildHybrid closed-loopType 1 diabetes

Identifiers

PMID42812143
PMCPMC13599426

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.