Evidence map›Paper›PMID 42812169›Full record

ArticleFrontiers in medicine2026

Patient-specific osteoarticular reconstruction of the proximal tibia for giant cell tumor using a 3D-printed trabecular implant and hinged knee arthroplasty: a case report.

Mauricio Olmedo-López, Mauro Damian Belzino, Jorge Pérez-Soliz, Jorge Vasconez-Gonzalez, Fanny K Tupiza-Luna, Galo S Guerrero-Castillo, Juan S Izquierdo-Condoy, Esteban Ortiz-Prado

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In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mauricio Olmedo-LópezOrthopedic Surgery Resident, Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina.
Mauro Damian BelzinoSpecialist in Orthopedic Surgery, Specialist in Orthopedic Oncology, Staff Physician, Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina.
Jorge Pérez-SolizSpecialist in Orthopedic Surgery, Foot and Ankle Fellowship, Trauma Center, Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina.
Jorge Vasconez-GonzalezOne Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Fanny K Tupiza-LunaDepartamento de Traumatologia y Ortopedia, Hospital Pablo Arturo Suarez, Quito, Ecuador.
Galo S Guerrero-CastilloOne Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Juan S Izquierdo-CondoyOne Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Esteban Ortiz-PradoOne Health Research Group, Universidad de Las Américas, Quito, Ecuador.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Giant cell tumor of bone (GCTB) is a benign but locally aggressive primary bone tumor that frequently affects the epiphyseal-metaphyseal region of long bones, particularly around the knee. In rare cases, it may undergo malignant trans-formation or metastasize. Case presentation: We report the case of a 62-year-old woman with a 5-year history of left knee pain, progressive deformity, and functional limitation. Imaging studies and biopsy confirmed a giant cell tumor of the proximal tibia with extensive epiphyseal involvement and articular collapse. The patient underwent oncologic resection using patient-specific cutting guides, followed by reconstruction with a custom 3D-printed porous trabecular Ti6Al4V-ELI implant manufactured by selective laser melting on a Renishaw AM400 system, combined with hinged total knee arthroplasty. The extensor mechanism was reinserted through dedicated fixation slots, and soft-tissue coverage was achieved with a medial gastrocnemius flap and polypropylene mesh. At 6 months, radiographs showed satisfactory alignment and early structural integration, with no evidence of local recurrence or implant loosening. Clinically, the patient achieved full weight-bearing and an excellent functional outcome. Conclusion: This case suggests that patient-specific reconstruction combining virtual planning, 3D printing, and porous trabecular design may be a feasible limb-salvage option for selected proximal tibial GCTB with major osteoarticular destruction.

Indexed as

arthroplastycase reportgiant cell tumor of bonekneeknee prosthesisosseointegrationreplacementthree-dimensional printing

Identifiers

PMID42812169
PMCPMC13619408

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.