ArticleFrontiers in medicine2026
Patient-specific osteoarticular reconstruction of the proximal tibia for giant cell tumor using a 3D-printed trabecular implant and hinged knee arthroplasty: a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Giant cell tumor of bone (GCTB) is a benign but locally aggressive primary bone tumor that frequently affects the epiphyseal-metaphyseal region of long bones, particularly around the knee. In rare cases, it may undergo malignant trans-formation or metastasize. Case presentation: We report the case of a 62-year-old woman with a 5-year history of left knee pain, progressive deformity, and functional limitation. Imaging studies and biopsy confirmed a giant cell tumor of the proximal tibia with extensive epiphyseal involvement and articular collapse. The patient underwent oncologic resection using patient-specific cutting guides, followed by reconstruction with a custom 3D-printed porous trabecular Ti6Al4V-ELI implant manufactured by selective laser melting on a Renishaw AM400 system, combined with hinged total knee arthroplasty. The extensor mechanism was reinserted through dedicated fixation slots, and soft-tissue coverage was achieved with a medial gastrocnemius flap and polypropylene mesh. At 6 months, radiographs showed satisfactory alignment and early structural integration, with no evidence of local recurrence or implant loosening. Clinically, the patient achieved full weight-bearing and an excellent functional outcome. Conclusion: This case suggests that patient-specific reconstruction combining virtual planning, 3D printing, and porous trabecular design may be a feasible limb-salvage option for selected proximal tibial GCTB with major osteoarticular destruction.
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