Evidence map›Paper›PMID 42812205›Full record

ArticleFrontiers in immunology2026

A systems-level analysis of global gene expression in resistant and susceptible

Abdelmalek Lekired, Coen M Adema, Si-Ming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abdelmalek LekiredCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Coen M AdemaCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Si-Ming ZhangCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.

Funding

Genetics and genomics of schistosome resistance in snailsR01AI170587 · NIAID · UNIVERSITY OF NEW MEXICO · PI ZHANG, SI-MING · 2022 to 2025
$2.8M
Fine-resolution genetic mapping of advanced intercross lines of Biomphalaria glabrataR21AI193098 · NIAID · UNIVERSITY OF NEW MEXICO · PI ZHANG, SI-MING · 2025 to 2025
$430k
NIAID NIH HHS HHSN272201700014CNIAID NIH HHS R01 AI170587NIAID NIH HHS R21 AI193098
6 · The paper itself

Abstract

Background: The freshwater gastropod Methods: Two new Results: Each snail line exhibited a different basal transcriptional profile, including immune genes involved in parasite recognition and defense, such as genes encoding lectins, variable immunoglobulin and lectin domain-containing proteins (VIgLs) including fibrinogen-related proteins (FREPs), fibrinogen domain-containing proteins (FReDs), avrRpt2-induced gene products (AIGs), and GTPase immunity-associated proteins (GiMAPs). Resistant lines showed higher constitutive expression of some candidate defense genes, including biomphalysin, Conclusions: This systems-level comparative analysis of two models with four genetically distinct

Indexed as

BiomphalariaDisease ResistanceHost-Parasite InteractionsSchistosoma mansoniSchistosomiasis mansoniTranscriptomeAnimalsDisease SusceptibilityGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksBiomphalaria glabrataconstitutive gene expressiongene co-expression networkinducible gene expressionrecombinant inbred lineschistosomiasistranscriptome

Identifiers

PMID42812205
PMCPMC13619432

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.