ArticleFrontiers in medicine2026
Plasma amino acid metabolic alterations and their associations with ocular parameters in early primary angle-closure glaucoma.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To explore the plasma metabolite profiles of patients with early primary angle-closure glaucoma (PACG) and investigate their relevance to ocular characteristics and retinal-associated parameters. Methods: Plasma samples were obtained from 30 early PACG patients and 30 healthy controls for untargeted and targeted metabolomics analysis. Additionally, relevant clinical data such as ocular characteristics and retinal-associated parameters were collected. Correlations between clinical data and differential metabolites were further analyzed. Results: A total of 439 differential metabolites were identified through untargeted metabolomics analysis, with amino acids being the most abundant category among the differential metabolites. Amino acid-targeted metabolomics revealed that L-alanine, L-lysine, citrulline, L-tyrosine, and glycylglycine were significantly elevated in early PACG (all Conclusion: The plasma of early PACG patients showed distinctive metabolic profiles, which provided new insights into the pathogenesis of the early phase of PACG patients.
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