ArticleFrontiers in digital health2026
Growing public interest and regional disparities of cardiorenal syndrome in the United States.
Article in Frontiers in digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Public awareness and regional engagement with cardiorenal syndrome (CRS) remain poorly understood. We examined temporal trends and geographic patterns of U.S. public interest in CRS and their relationship with disease burden. Methods: Google Trends™ data (2004-2025) annual relative search interest (RSI) for CRS. CRS-related mortality was derived from CDC WONDER (2007-2020) using hypertensive heart and chronic kidney disease deaths. Temporal trends were assessed via augmented Dickey-Fuller tests and linear regression. Associations between RSI and mortality were evaluated using Pearson correlation, AR(1) modeling, first-difference, and cumulative change analysis. State-level correlations were examined with and without adjustment for income, education, and insurance coverage. Results: Both RSI and mortality exhibited strong non-stationary upward trend ( Conclusion: Public interest in CRS has grown in parallel with mortality, reflecting its increasing epidemiological relevance. However, the lack of geographic correlation between search interest and mortality-even after socioeconomic adjustment-suggests awareness gaps and highlights opportunities for targeted education and resource allocation.
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