Evidence map›Paper›PMID 42812516›Full record

ArticleClinical case reports2026

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2.

Mehri Salari, Arash Soltani, Masoud Etemadifar, Kamran Rezaei

Abstract read
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In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehri SalariSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-1675-681X
Arash SoltaniStudent Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.
Masoud EtemadifarFaculty of Medicine Isfahan University of Medical Sciences Isfahan Iran.
Kamran RezaeiStudent Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-0451-3175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism. Clinicians should consider CHCHD2 in familial dementia with pyramidal signs, even when motor parkinsonism is absent.

Indexed as

CHCHD2geneticParkinson's diseasepyramidal signs

Identifiers

PMID42812516
PMCPMC13620204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.