ArticleFrontiers in pediatrics2026
Sequential exposure to histological chorioamnionitis and postnatal hyperoxia alters gene expression in cord blood monocytes.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sequential exposure to heterologous noxious stimuli such as histological chorioamnionitis (HCA) and hyperoxia may elicit variable immune responses, resulting in distinct disease manifestations in the neonate. However, the molecular mechanisms underlying innate immune dysregulation in these contexts remain poorly characterized. Methods: We conducted a pilot prospective observational study evaluating global gene expression in cord blood monocytes obtained from term infants born to mothers with and without HCA. Monocytes were exposed Results: We studied monocytes from 14 neonates (HCA Conclusions: Sequential exposure to histological chorioamnionitis and postnatal hyperoxia induces alterations in gene expression and molecular pathways in neonatal cord blood monocytes, affecting immune regulation, which could potentially contribute to the pathogenesis of short- and long-term diseases.
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