Evidence map›Paper›PMID 42812771›Full record

ReviewFrontiers in cell and developmental biology2026

Ferroptosis in smoke inhalation injury: from mechanisms to potential therapeutic targets.

Nayab Ibrahim, Jinchao Zhu, Yanqing Liu, Chuanlong Li, Ningning Shao, Wenping Fan, Yue Shi, Jianxin Li, Jinrui Dong, Haojun Fan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nayab Ibrahim *Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Jinchao Zhu *Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Yanqing Liu *Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Chuanlong LiWenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, Zhejiang, China.
Ningning ShaoState Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University, Tianjin, China.
Wenping FanState Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University, Tianjin, China.
Yue ShiWenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, Zhejiang, China.
Jianxin LiKey Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Jinrui DongKey Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Haojun FanKey Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smoke inhalation injury (SII) is a prevalent yet underrecognized cause of acute respiratory failure and longer-term airway-alveolar remodeling after fires, wildfires, and industrial accidents. Beyond inflammation and generic oxidative stress, accumulating evidence supports ferroptosis as a mechanistically distinct, self-amplifying axis that can sustain epithelial/endothelial damage, barrier breakdown, and maladaptive repair. Ferroptosis is driven by iron-dependent phospholipid peroxidation and collapse of membrane redox homeostasis, and in SII is promoted by iron dyshomeostasis including heme/hemoglobin-derived iron and ferritinophagy, PUFA-phospholipid remodeling, and failure of antioxidant checkpoints centered on the System Xc

Indexed as

biomarkersferroptosisoxidative stresssmoke inhalation injurytherapeutic targets

Identifiers

PMID42812771
PMCPMC13620227

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.