ArticleIndian journal of psychiatry2026
Utility of clozapine trough level reporting in clinical practice: A four-year retrospective evaluation from India.
Article in Indian journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Clozapine therapeutic drug monitoring (TDM) supports individualized dosing in treatment-resistant schizophrenia. Aim: This study evaluated the time trend of TDM reporting in routine practice. Methods: A retrospective audit of 100 consecutive clozapine TDM reports over 4 years was performed. Service utilization was assessed. Associations between daily dose, trough concentration, concentration-dose (C/D) ratio, therapeutic impressions (low, matching the dose, high, very high clozapine concentrations), and clinical advice accordingly were analyzed statistically. Results: The mean turnaround time was 20.9 ± 12 days, with a stable quarterly demand (~6 requests/quarter) for clozapine TDM. Dose correlated significantly with trough concentration (ρ = 0.453, Conclusions: Pharmacology TDM service utilization for clozapine was steady and continuing in treatment-resistant schizophrenia patient care.
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