ArticleChemical science2026
Flexible receptor architectures for anion recognition
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Phosphate anions play key roles in biology, chemistry, the environment, and are important industrial raw materials. However, their recognition, binding, and sensing in water are complicated by their structural diversity, multiple protonation states, and strong hydration. Well-pre-organized macrocyclic receptors are used to increase selectivity and affinity by reducing the entropy associated with the adaptation of the receptor to the phosphate guests. However, the synthesis and purification of macrocyclic sensors is difficult, marred by low yields. Linear (non-macrocyclic) receptors and sensors are easy to synthesize and purify, but may display lower overall affinity and selectivity. We explored the utility of simple linear sensors that contain ionic hydrogen-bonding donors, namely ammonium, isothiouronium, and guanidinium, for phosphorus oxyanions. Anion binding was investigated by NMR spectroscopy and X-ray crystallography. Quantitative binding was determined by fluorescence titrations. Titrations revealed the general order of affinity to be H
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