ArticleNucleic acids research2026
CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We developed CUT&ID to simultaneously profile the native genomics and proteomics associations of any endogenous target, in a single workflow with no need for transgenesis. CUT&ID is enabled by a fusion protein of TurboID, protein A/G, and micrococcal nuclease, which drives sequential target recognition, proximal protein biotinylation, and DNA cleavage in living cells. CUT&ID is broadly applicable, works on fresh, frozen, or fixed nuclei, and provides high signal-to-noise genomics and proteomics identification across all types of gene regulators tested, including histone modifications, transcription factors, and non-DNA-binding proteins. CUT&ID's streamlined protocol yields a dual readout from 1 million cells per sample, making it an attractive alternative to existing methodologies.
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