Evidence map›Paper›PMID 42814017›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase.

Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong-Wan Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chang Woo KoDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-3575-1309
Dongyoon ShinDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-5493-5026
Junho ParkDepartment of Medical Science, School of Medicine, CHA University, Seongnam, Republic of Korea.ORCID https://orcid.org/0000-0003-1678-5968
June HuhDepartment of Chemical and Biological Engineering, Korea University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-4610-4521
Youngsoo KimDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-8881-0662
Jong-Wan ParkDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-4676-5191

Funding

National Research Foundation of Korea 2022R1A2C2091397National Research Foundation of Korea RS-2023-00218623
6 · The paper itself

Abstract

Galactokinase 1 (GALK1) is a metabolic kinase that phosphorylates galactose. Mutations in GALK1 cause type II galactosemia, which manifests as cataracts and extra-ocular symptoms. The mechanisms underlying these symptoms are not fully understood. In this study, we explored a novel function of GALK1 beyond galactose phosphorylation. GALK1 is ubiquitously expressed across human tissues, regardless of developmental stage. GALK1 phosphorylates TIMM13 at the Y73 residue. The phosphorylated Y73 stabilizes TIMM13 by electrostatically interacting with two cationic residues, thereby enhancing its affinity for Zn

Indexed as

GALK1mitochondrial respirationprotein kinaseTIMM13

Identifiers

PMID42814017
PMCPMC13625921

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.