Evidence map›Paper›PMID 42814036›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026

Controlling Meiotic Double-Strand Break Formation in Mice: A Web of Multivalent Protein-Protein Interactions.

Jiaqi Xu, Scott Keeney

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jiaqi XuState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.ORCID https://orcid.org/0009-0006-6348-3769
Scott KeeneyWeill Cornell Graduate School of Medical Sciences, New York, New York, USA.ORCID https://orcid.org/0000-0002-1283-6417

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Howard Hughes Medical InstituteNational Natural Science Foundation of China 82401943NCI NIH HHS P30 CA008748U.S. National Cancer Institute P30 CA08748
6 · The paper itself

Abstract

A complex network of protein interactions promotes the cooperative assembly of biomolecular condensates that control the formation of meiotic DNA double-strand breaks (DSBs). In many species, programmed DSBs made by SPO11 are required for the faithful pairing and segregation of homologous chromosomes during meiosis I. DSBs must be tightly regulated to support their intended function but also to minimize the risk of genomic damage from mutation or defective DSB repair. Multiple chromosome axis-associated proteins are important for the control of meiotic DSB formation and recombination, but the underlying mechanisms of those proteins remain poorly understood. Here, we present a current view of how these proteins work together in mice, based on recent advances in the characterization of their function and structure.

Indexed as

DNA Breaks, Double-StrandedMeiosisAnimalsDNA RepairEndodeoxyribonucleasesHomologous RecombinationMeiotic Recombination Protein SPO11MiceEndodeoxyribonucleasesMeiotic Recombination Protein SPO11DNA double‐strand breakshomologous recombinationmeiosis

Identifiers

PMID42814036
PMCPMC13637975

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.