ArticleEuropean geriatric medicine2026
Statin use and functional response to multicomponent exercise in acutely hospitalized older adults: secondary analysis of a randomized trial.
Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02300896 (Functional and Cognitive Impairment Prevention Through Early Physical Activity for Elderly Hospitalized Patients), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional and Cognitive Impairment Prevention Through Early Physical Activity for Elderly Hospitalized Patients: a Randomized Clinical Trial
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Authors and funding
6 authors.
Funding
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Abstract
purposeThis study investigated whether statin use modulates the functional benefits of a multicomponent exercise program during acute hospitalization in patients aged > 75 years.
methodsWe conducted a secondary analysis of a randomized controlled trial (NCT02300896) involving 310 participants (average age 87 years, 58.7% women). The intervention group received supervised exercise, whereas the control group received standard care. The primary outcome was change in the Barthel Index (BI).
resultsOverall, exercise improved functional outcomes, regardless of statin use. Although exploratory adjusted models suggested a potentially greater Barthel Index improvement in statin users compared to non-users (mean difference 5.58 points; 95% CI 0.44 to 10.7; p = 0.035), this finding should be interpreted with caution. No statin-related adverse muscle events were observed during the intervention.
conclusionsExercise interventions confer functional benefits during acute hospitalization regardless of statin use. While statin users exhibited greater improvement in Barthel Index scores, this exploratory finding requires cautious interpretation. Overall, these results reinforce the safety of maintaining statins in acutely ill older adults and support the implementation of exercise programs.
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