Evidence map›Paper›PMID 42814281›Full record

ReviewCurrent pain and headache reports2026

The Role of Behavioral and Psychological Interventions in Chronic Ocular Pain.

Radhika S Amin, Eliot N Haddad, Raghavan Gopalakrishnan, Sara McCormick, Pavan Tankha, Sara Davin, Rony R Sayegh

Abstract readReview
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Radhika S AminCole Eye Institute, Cleveland Clinic, 2042 East 102nd Street, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0009-0004-8012-6929
Eliot N HaddadCole Eye Institute, Cleveland Clinic, 2042 East 102nd Street, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0002-9207-7325
Raghavan GopalakrishnanCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Sara McCormickCenter for Spine and Pain Medicine, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Pavan TankhaCenter for Spine and Pain Medicine, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Sara DavinCenter for Spine and Pain Medicine, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Rony R SayeghCole Eye Institute, Cleveland Clinic, 2042 East 102nd Street, Cleveland, OH, 44106, USA. sayeghr@ccf.org.ORCID http://orcid.org/0000-0002-0119-4201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic ocular pain (COP) is a debilitating condition in which patients experience pain in or around the eyes. It is strongly associated with other pain and psychological conditions. Management options remain limited and available ocular therapies are rarely effective, particularly in patients with central sensitization. As in other pain conditions, psychological and behavioral interventions are important, yet understudied and underutilized in the management of COP. This review explores the literature pertaining to such interventions for COP. RECENT

findingsCOP, while previously thought of as dry eye disease, is now accepted as a separate pain entity. It overlaps with other chronic pain conditions and is also associated with depression, anxiety, post-traumatic stress disorder, sleep disturbance, pain catastrophizing, fear avoidance, and somatic symptom burden, which can be conceptualized through a biopsychosocial model. In broader chronic pain populations, cognitive behavioral therapy, mindfulness-based interventions, acceptance and commitment therapy, pain neuroscience education, emotional awareness and expression therapy, and behavioral interventions have demonstrated benefit for pain-related distress, coping, function, and disability. However, evidence supporting such interventions for COP remains limited, and no formal investigation of psychological interventions for COP has been published to date. The reviewed literature provides supportive evidence for psychological and behavioral interventions as mechanism-based adjuncts for COP management within a biopsychosocial framework. Integrating these approaches through multidisciplinary care models emphasizing pain psychology may help address central pain contributors and functional disability. COP-specific trials are needed to define which patients will most benefit, optimal interventions, and implementation models in practice.

Indexed as

Behavior TherapyChronic PainEye PainPain ManagementPsychosocial InterventionCognitive Behavioral TherapyHumansBehavioralBiopsychosocialChronic Ocular PainDry Eye DiseaseMultidisciplinaryPsychological

Identifiers

PMID42814281
PMCPMC13627212

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.