ReviewMolecular biology reports2026
An integrative review of wound healing: anatomy, molecular mediators, and indigenous therapies.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWound healing, an important biological process, is a process through which the human body repairs its skin from injuries through organized cell function, molecular signaling, and tissue remodeling. Chronic or delayed wound healing remains a major public health challenge around the world.
methodsA narrative review was conducted through searches in PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library for articles published between January 2005 and June 2026 by searching keywords such as "wound healing," "hemostasis," "growth factors," "signaling pathways," "chronic wound," "scar," "wound microbiome," and specific traditional treatments. Non-peer-reviewed papers, conference abstracts, and duplicate records were excluded. Only peer-reviewed primary studies, systematic reviews, meta-analysis, and Cochrane reviews published in English were included. The quality of selected articles was assessed by applying SANRA guidelines for narrative reviews and AMSTAR-2 checklist for cited systematic reviews.
resultsGrowth factors (PDGF, TGF-β, EGF, FGF, VEGF), their receptors and signaling pathways (SMAD, MAPK, PI3K/AKT, JAK/STAT, Wnt/β-catenin, Notch, Hippo/YAP-TAZ, mTOR and NF-κB) regulate the four overlapping stages of human skin wound healing (hemostasis, inflammation, and remodeling). Some bioactive substances which are antibacterial and regenerative in nature are contained in the local treatment methods like honey, Aloe vera, frog skin and maggot therapy; some of these treatments are backed up by Cochrane review-level evidence.
conclusionA path to safer and more effective wound treatment can be seen by integrating the molecular pathway, chronic wound biology, current biological therapies and evidence-based traditional medicine.
Indexed as
Identifiers
42814390What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.