Evidence map›Paper›PMID 42814410›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment.

Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yidan Zhou *School of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.
Zhuo Chang *Laboratory For Multiscale Mechanics and Medical Science, State Key Laboratory For Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Shaanxi, China.ORCID https://orcid.org/0000-0001-6202-2641
Xianjun WuLaboratory For Multiscale Mechanics and Medical Science, State Key Laboratory For Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Shaanxi, China.
Sijie WangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.
Yuzhi ZhangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.
Hao ZhangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.ORCID https://orcid.org/0000-0002-1455-8350
Haoyu XuSchool of Physical Science and Technology, Northwestern Polytechnical University, Shaanxi, China.
Ruining PengSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.
Zhe WangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.
Huiyun XuSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.ORCID https://orcid.org/0000-0002-4873-9934
Yu LiuDepartment of Cardiology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Jiangsu, China.
Guangkui XuLaboratory For Multiscale Mechanics and Medical Science, State Key Laboratory For Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi'an Jiaotong University, Shaanxi, China.ORCID https://orcid.org/0000-0001-6393-5434
Nu ZhangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.ORCID https://orcid.org/0000-0003-1285-0785
Hui YangSchool of Life Sciences and Technology, Northwestern Polytechnical University, Shaanxi, China.ORCID https://orcid.org/0000-0001-7567-3048

Funding

Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University CX2025102Medical School of Nanjing University 2024-LCYJ-MS-10National Natural Science Foundation of China 12002285National Science Foundation of Shaanxi 2025JC-YBMS-044
6 · The paper itself

Abstract

Atherosclerosis is the primary pathological basis for cardiovascular diseases. Despite advances in diagnosis and treatment, current methods primarily focus on late-stage intervention, missing critical opportunities for early detection. Recently, the dynamic mechanical properties of arterial tissue have been recognized as a novel approach for assessing vascular status, and offer an opportunity to employ the mechanical properties of atherosclerotic lesions for evaluating disease status and monitoring disease progression. Here, we employed a Hybrid Hierarchical theory-Microrheology (HHM) framework to quantify multiscale mechanical markers during lesion progression. The results revealed a two-stage power-law rheology, with short- and long-timescale exponents (α

Indexed as

atherosclerosismultiscale mechanicsviscoelastic properties

Identifiers

PMID42814410
PMCPMC13626170

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.