Evidence map›Paper›PMID 42814554›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation.

He Ren, Hyun-Ro Lee, Yannick A D Omar, Joseph B DeGrandchamp, Chien-Lun Hung, Timothy J Eisen, Dimitrios Stamou, John Kuriyan, Arup K Chakraborty, Jay T Groves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

He Ren *Department of Chemistry, University of California, Berkeley, CA 94720.ORCID 0009-0007-2838-835X
Hyun-Ro Lee *Department of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-1780-940X
Yannick A D OmarDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0009-0000-6700-2519
Joseph B DeGrandchampDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0003-2194-5495
Chien-Lun HungDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37240.ORCID 0000-0002-2546-1132
Timothy J EisenDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-4812-4171
Dimitrios StamouDepartment of Chemistry, University of Copenhagen, Copenhagen DK-2100, Denmark.
John KuriyanDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37240.ORCID 0000-0002-4414-5477
Arup K ChakrabortyDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-1268-9602
Jay T GrovesDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-3037-5220

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2011 to 2026
$31.1M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) PO1 A1091580NIAID NIH HHS P01 AI091580Novo Nordisk Fonden (NNF) Center for Geometrically Engineered Cellular Systems
6 · The paper itself

Abstract

T cells can respond to even a single molecular binding event of antigen to a TCR. A key step in the TCR signaling pathway that definitively exhibits this single-molecule response is the initiation of calcium influx by activation of PLCγ1 in the LAT protein condensate. Here, we describe detailed kinetic measurements examining how protein condensation of LAT regulates activation of PLCγ1 using a reconstituted membrane system. The results reveal that membrane recruitment of PLCγ1 is tightly controlled by the LAT phosphorylation state, with no measurable independent recruitment to PIP

Indexed as

Adaptor Proteins, Signal TransducingMembrane ProteinsPhospholipase C gammaAnimalsEnzyme ActivationHumansKineticsPhosphorylationReceptors, Antigen, T-CellSignal TransductionT-LymphocytesAdaptor Proteins, Signal TransducingLAT protein, humanMembrane ProteinsPhospholipase C gammaPLCG1 protein, humanReceptors, Antigen, T-Cellkineticsphospholipase C gammaprotein condensationT cell receptor signaling

Identifiers

PMID42814554
PMCPMC13643308

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.