Evidence map›Paper›PMID 42814813›Full record

ArticleScience advances2026

PI(3,5)P

Jiachen Sun, Julian Zalejski, Seohyeon Song, Ashutosh Sharma, Wei Wang, Yusi Hu, Wen-Ting Lo, Philipp Alexander Koch, Duy-Viet Vo, Jagriti Singh and 9 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jiachen SunDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-0278-6831
Julian ZalejskiDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0009-0006-5024-8647
Seohyeon SongDivision of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea.
Ashutosh SharmaDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-0455-9963
Wei WangDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0009-0007-3019-2479
Yusi HuDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Wen-Ting LoLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0001-7904-6834
Philipp Alexander KochLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0003-0543-7482
Duy-Viet VoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-9268-6358
Jagriti SinghDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Indira SingaramDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Baoshu AnDepartment of Biological Sciences, University of Illinois Chicago, Chicago, IL 60607, USA.
Hirushi GunasekaraDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Jean J ZhaoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-4561-5688
Liang-Wei GongDepartment of Biological Sciences, University of Illinois Chicago, Chicago, IL 60607, USA.
Ying S HuDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-3912-7063
Volker HauckeLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Ruixuan GaoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-7137-2512
Wonhwa ChoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-1410-2481

Funding

Integrating targeted therapy and immunotherapy to break through cancerR35CA210057 · NCI · DANA-FARBER CANCER INST · PI Jean Zhao · 2016 to 2026
$10.8M
Supplement for Equipment for Lipid Regulation of Cellular Signaling and Protein-Protein InteractionsR35GM122530 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WONHWA CHO · 2017 to 2026
$6.1M
Ultrasensitive quantification of cytokine release from T cellsR35GM146786 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ying Samuel Hu · 2022 to 2026
$2.2M
The role of a calcium permeable TRP channel in endocytosisR56MH107387 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GONG, LIANG-WEI · 2016 to 2016
$393k
NCI NIH HHS R35 CA210057NIGMS NIH HHS R35 GM122530NIGMS NIH HHS R35 GM146786NIMH NIH HHS R56 MH107387
6 · The paper itself

Abstract

3-Phosphoinositides are essential cellular lipids regulating health and disease. Among them, phosphatidylinositol-3,5-bisphosphate [PI(3,5)P

Indexed as

Class I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesSignal TransductionAnimalsEndosomesHumansLysosomesMiceProtein BindingClass I Phosphatidylinositol 3-Kinasesphosphatidylinositol 3,5-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol Phosphates

Identifiers

PMID42814813
PMCPMC13626037

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.