Evidence map›Paper›PMID 42815877›Full record

SynthesisClinical psychology & psychotherapy

Attachment Styles in Major Depressive Disorder: A Systematic Review and Meta-Analysis.

Lingfeng Xue, Virginia Chi Tong Chau, Anokhi Mehra, Rachel Woodham, Gabrielle Sheehan, Valentina Lorenzetti, Michal W S Ong, Muzzammil Hussain, Anna J Lawes, Ramesh Muthuswamy and 1 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Clinical psychology & psychotherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingfeng XueCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0002-9922-5554
Virginia Chi Tong ChauCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0009-0006-6441-0924
Anokhi MehraCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Rachel WoodhamCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0002-5581-9449
Gabrielle SheehanCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4646-0494
Valentina LorenzettiSchool of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.ORCID https://orcid.org/0000-0002-5917-7068
Michal W S OngCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0009-0001-7614-9018
Muzzammil HussainImperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.
Anna J LawesDepartment of Psychology, University of East London, London, UK.
Ramesh MuthuswamySouth London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0009-0003-0895-0289
Cynthia H Y FuCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4313-3500

Funding

Disentangling the anatomical, functional and clinical heterogeneity of major depression, using machine learning methodsR01MH134236 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, FU, CYNTHIA · 2023 to 2024
$1.5M
International Psychoanalytic Association 158102845Milken Institute Baszucki Brain Research Fund BD0000000029National Institute for Health and Care Research NIHR165425NIHR Efficacy and Mechanisms Evaluation NIHR167361NIMH NIH HHS R01 MH134236NIMH NIH HHS R01MH134236Rosetrees Trust CF20212104Rosetrees Trust CF2024M2116
6 · The paper itself

Abstract

Major depressive disorder (MDD), a leading cause of disability, is associated with difficulties in close relationships. Attachment theory links early caregiving to internal working models shaping emotion regulation, interpersonal functioning and depression vulnerability. Attachment patterns in clinically diagnosed MDD have not been synthesised. Following PRISMA (PROSPERO: CRD42017068580), we searched for studies of adults with standardised diagnoses of MDD or postpartum depression (PPD) and attachment measures. Random-effects meta-analyses expressed categorical outcomes as odds ratios (ORs) and continuous outcomes as Hedges' g. As a result, 61 studies met inclusion criteria: 33 case-control and 28 depression-only, of which five provided qualitative data only. Categorically, MDD/PPD showed lower secure (OR = 0.20, 95% CI 0.15-0.26, p < 0.001) and higher anxious (OR = 2.46, 1.66-3.64, p < 0.001), avoidant (OR = 1.42, 1.04-1.95, p = 0.027) and fearful attachment (OR = 3.00, 1.97-4.54, p < 0.001) than healthy controls. On continuous measures, secure attachment was lower (g = -0.46, p = 0.003) and anxious (g = 0.63, p < 0.001) and avoidant (g = 0.41, p = 0.011) higher; fearful was not significant (g = 0.35, p = 0.062) until an outlier was removed. Single-arm prevalence meta-analyses found secure attachment in 24.1%, fearful in 26.9%, avoidant in 23.7% and anxious in 23.0%, with secure more prevalent in PPD than MDD (31.9% versus 21.3%, p = 0.009). In conclusion, MDD and PPD show lower secure and higher anxious, fearful and avoidant attachment than healthy controls. About three in four patients show insecure attachment, supporting attachment-informed assessment and treatment planning.

Indexed as

Major Depressive DisorderObject AttachmentAdultDepression, PostpartumFemaleHumansadult attachmentattachment anxiety and avoidanceinsecure attachmentmajor depressive disordermeta‐analysispostpartum depression

Identifiers

PMID42815877
PMCPMC13626741

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.