ArticleMolecular psychiatry2026
Investigating the associations between neurodevelopmental and psychiatric genetic liability and adverse social and functional outcomes across childhood, adolescence and young-adulthood.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Neurodevelopmental and psychiatric conditions often originate in youth and can lead to adverse social and functional outcomes. It is unclear whether these associations are driven by genetic liability to these conditions, with possible developmental differences. We examined multivariable associations between polygenic scores (PGS) for attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), schizophrenia, bipolar disorder, depression, anxiety and three outcomes: peer problems, educational attainment/employment and suicidality, in childhood, adolescence and young-adulthood. Data were analysed from the Avon Longitudinal Study of Parents and Children; outcomes at ages 10-13, 16 and 24-25 years. ADHD PGS was associated with peer problems (OR = 1.13, p = 0.020; OR = 1.21, p < 0.0001; OR = 1.14, p = 0.010) and lower educational attainment/employment in childhood, adolescence and young-adulthood(OR = 1.40, p < 0.0001; OR = 1.62, p < 0.0001; OR = 1.29, p = 0.005 respectively) and suicidality in childhood (OR = 1.13, p = 0.030). ASD PGS was associated with peer problems and suicidality in childhood (OR = 1.24, p < 0.0001; OR = 1.24, p = <0.0001) and greater educational attainment in childhood and adolescence (OR = 0.88, p = 0.004; OR = 0.77, p = 0.007). Depression PGS was associated with peer problems in childhood and young-adulthood (OR = 1.18, p = 0.003; OR = 1.21, p < 0.0001), and poorer educational attainment/employment and suicidality in adolescence (OR = 1.39, p = 0.004; OR = 1.28, p < 0.0001) and young-adulthood (OR = 1.26, p = 0.017; OR = 1.42, p < 0.0001). We did not find strong evidence of associations for schizophrenia, bipolar disorder or anxiety PGS. These findings suggest that genetic liability to neurodevelopmental and psychiatric conditions are associated with a range of social/functional outcomes, although the strength and direction of association vary by PGS, outcome and development stage. This highlights the importance of examining genetic liability to multiple conditions simultaneously and of a developmental perspective.
Identifiers
42816538What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.