Evidence map›Paper›PMID 42816619›Full record

ArticleNature2026

GPCR antagonism via rewiring of receptor trafficking and degradation.

Kaitlin Rhee, Lawrence Shue, Akimasa Adachi, Pengwei Sun, James Osei-Owusu, Dingjingyu Zhou, Aoxing Cheng, Yi Ran Xu, Qingyue Li, Apoorva Baluapuri and 7 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kaitlin Rhee *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0168-8946
Lawrence Shue *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4525-9270
Akimasa AdachiDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Pengwei SunWu-Tsai Neuroscience Institute, Stanford University, Stanford, CA, USA.
James Osei-OwusuDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8676-4444
Dingjingyu ZhouDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Aoxing ChengDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9143-2199
Yi Ran XuDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Qingyue LiWu-Tsai Neuroscience Institute, Stanford University, Stanford, CA, USA.
Apoorva BaluapuriDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3723-7891
Edward P HarveyDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Karen AdelmanDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5364-334X
Meredith A SkibaDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4615-6775
Bianxiao CuiWu-Tsai Neuroscience Institute, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8044-5629
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1540-6244
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Andrew_Kruse@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1467-1222
Xin ZhouDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Xin_Zhou1@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-8198-2856

Funding

Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolutionR01CA260415 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KRUSE, ANDREW, LIU, CHANG C · 2020 to 2024
$8.4M
Probing the specificity and activity of the metazoan Integrator complexR01GM134539 · NIGMS · HARVARD MEDICAL SCHOOL · PI Karen L Adelman, ERIC J WAGNER · 2019 to 2026
$4.7M
Training in Pharmacological SciencesT32GM132089 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID E. GOLAN, Timothy J Mitchison · 2019 to 2026
$3.7M
The Conundrum of Absentee Receptors: Efficacy Potentiation Through Drug-Receptor ModulationR01AR081264 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Andrew Kruse · 2022 to 2026
$3.2M
Sustained Release Relaxin-2 for the Treatment of Frozen ShoulderR01AR079489 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Andrew Kruse · 2022 to 2026
$3.0M
Engineering programmable enzymes for proteome editingDP2GM154013 · NIGMS · DANA-FARBER CANCER INST · PI Xin Zhou · 2023 to 2026
$2.7M
Harvard Chemical Biology PhD ProgramT32GM139775 · NIGMS · HARVARD UNIVERSITY · PI Emily Patricia Balskus, PHILIP A COLE · 2022 to 2026
$2.6M
Label-free Optical Recording of Neuroelectric ActivitiesR01NS121934 · NINDS · STANFORD UNIVERSITY · PI CUI, BIANXIAO, MUELLER, HOLGER · 2021 to 2025
$2.2M
Targeting cancer metastasis by inhibiting curvature-induced kinase activationR01CA311218 · NCI · STANFORD UNIVERSITY · PI Bianxiao Cui · 2025 to 2026
$2.0M
Interrogating and rewiring cell signaling pathways in CAR-T cells with synthetic phosphotyrosine recognition domainsR00EB030587 · NIBIB · DANA-FARBER CANCER INST · PI ZHOU, XIN · 2022 to 2024
$733k
Employing biologics to probe GPCR signaling in maternal and fetal healthK99HD110612 · NICHD · HARVARD MEDICAL SCHOOL · PI SKIBA, MEREDITH ANNE · 2023 to 2024
$249k
NCI NIH HHS R01 CA260415NCI NIH HHS R01 CA311218NIAMS NIH HHS R01 AR079489NIAMS NIH HHS R01 AR081264NIBIB NIH HHS R00 EB030587NICHD NIH HHS K99 HD110612NIGMS NIH HHS DP2 GM154013NIGMS NIH HHS R01 GM134539NIGMS NIH HHS T32 GM132089NIGMS NIH HHS T32 GM139775NINDS NIH HHS R01 NS121934
6 · The paper itself

Abstract

G-protein-coupled receptors (GPCRs) represent one of the most important yet incompletely addressed classes of therapeutic targets

Identifiers

PMID42816619
PMCPMC13632652

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.