Evidence map›Paper›PMID 42817043›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2-Mediated µ-Opioid Receptor Internalization.

Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue-Jun Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo PengDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0009-0008-2228-3079
Xiaqing LinDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0009-0002-5250-3761
Hongyu YaoDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0000-0002-2621-474X
Cheng LiDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0009-0004-9141-6286
Huabao LiaoDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yuexin LiuDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0009-0009-7320-2942
Boxu CaoDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Xue-Jun SongDepartment of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0000-0003-4386-9868

Funding

National Natural Science Foundation of China 81971062National Natural Science Foundation of China 82471250Shenzhen Science and Technology Program JCYJ20220818100615033Shenzhen Science and Technology Program KQTD20200820113040070
6 · The paper itself

Abstract

Opioids are the primary treatment for severe pain in clinical practice. However, repeated exposure to opioids leads to tolerance, and underlying mechanisms remain elusive. The present study demonstrates that EphB1 receptors play an important role in opioid antinociception through orchestrating µ-opioid receptor (MOR) trafficking. Morphine administration activates EphB1 receptors in the dorsal root ganglion (DRG) and the spinal cord. Deletion of EphB1 receptors in DRG neurons or vesicular glutamate transporter 2 (Vglut2)-expressing neurons in the spinal dorsal horn (DH) augments morphine antinociception. MOR and EphB1 receptors are co-expressed in the somata and axons of DRG neurons and DH Vglut2

Indexed as

dorsal root ganglionEphB1 receptorGRK2phosphorylationspinal cordµ‐opioid receptor trafficking

Identifiers

PMID42817043
PMCPMC13627775

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.