Evidence map›Paper›PMID 42818062›Full record

ArticlebioRxiv : the preprint server for biology2026

Pathogenic variants of the mitochondrial copper chaperones SCO1 and SCO2 reshape their respective interactomes and disrupt cellular phospholipid metabolism.

Sampurna Ghosh, Zakery N Baker, Rachel M Guerra, Hana Antonicka, Abhinav B Swaminathan, Vishal M Gohil, David J Pagliarini, Stanley A Moore, Scot C Leary

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sampurna GhoshDepartment of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N5E5 Canada.
Zakery N BakerDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110 USA.
Rachel M GuerraDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110 USA.
Hana AntonickaThe Neuro, McGill University, Montreal, QC H3A 2B4 Canada.
Abhinav B SwaminathanDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843 USA.
Vishal M GohilDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843 USA.
David J PagliariniDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110 USA.
Stanley A MooreDepartment of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N5E5 Canada.
Scot C LearyDepartment of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N5E5 Canada.ORCID 0000-0002-0001-0087

Funding

Systems-to-structure approaches for defining mitochondrial protein functionR35GM131795 · NIGMS · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2019 to 2026
$4.8M
Mitochondrial Copper BiologyR35GM152102 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Vishal Mahendrasingh Gohil · 2024 to 2026
$1.7M
NIGMS NIH HHS R35 GM131795NIGMS NIH HHS R35 GM152102
6 · The paper itself

Abstract

SCO1 and SCO2 are required for copper delivery to COX2, a copper-containing subunit of cytochrome

Identifiers

PMID42818062
PMCPMC13622255

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.