Evidence map›Paper›PMID 42818346›Full record

ArticlebioRxiv : the preprint server for biology2026

A panel of Diversity Outbred mouse embryonic stem cells: enabling the functional characterization of natural genetic variation

Morgan M Brady, Emily Swanzey, Kathryn Janeczko, Samuel J Widmayer, Hannah B Dewey, Selcan Aydin, Whitney Martin, Catherine Brunton, Anuj Srivastava, Daniel M Gatti and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Morgan M BradyMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-1650-6167
Emily SwanzeyMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-2581-6498
Kathryn JaneczkoMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0009-0007-6133-8426
Samuel J WidmayerGenomic Medicine, The Jackson Laboratory, Farmington, CT, USA.ORCID 0000-0002-1200-4768
Hannah B DeweyMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-3009-0452
Selcan AydinMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-0457-9641
Whitney MartinMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.
Catherine BruntonMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-8502-6693
Anuj SrivastavaMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-8455-3993
Daniel M GattiMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-0667-9926
Laura G ReinholdtMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-4054-4048
Steven C MungerMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-8458-1871
Christopher L BakerMammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0001-6677-0356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenotypic variation in pluripotent stem cells arises largely from genetic variants that impact stability of the pluripotent state, response to differentiation cues, and cell fate diversification. Panels derived from genetic reference populations leverage genetic diversity to map the loci influencing these molecular and cellular traits. Here we describe the first publicly available resource for

Indexed as

cadmiumcomplex trait geneticsdifferentiationembryoid bodiesembryonic stem cellsgene-by-environment interactionspluripotencytoxicogenomic screen

Identifiers

PMID42818346
PMCPMC13622625

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.