Evidence map›Paper›PMID 42818366›Full record

ArticlebioRxiv : the preprint server for biology2026

Complement component C4 regulates amyloid pathology and glial reactivity in mouse model of Alzheimer's Disease.

Collin J Nadarajah, Michelle Y Li, Sohui Park, Jennifer H Lawrence, Ashish Sharma, Emma P Danhash, Celeste M Karch, Erik S Musiek

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Collin J NadarajahDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Michelle Y LiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Sohui ParkDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer H LawrenceDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Ashish SharmaDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Emma P DanhashDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Celeste M KarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Erik S MusiekDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8873-0360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complement system, a proteolytic cascade crucial for innate immune system function, is dysregulated in brain aging and neurodegenerative diseases, including Alzheimer Disease (AD). In models of AD, complement proteins, including C1q and C3, are upregulated and mediate microglial clearance of amyloid plaques and pruning of synapses. Among complement genes,

Identifiers

PMID42818366
PMCPMC13622655

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.