Evidence map›Paper›PMID 42818673›Full record

ArticlebioRxiv : the preprint server for biology2026

Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales.

James Newton Brandt, Alessandra Bonito-Oliva, Navid Paknejad, Celine Chen, John Fak, Andrew Luskin, Genelle Rankin, Miriam Kirylo, Leslie J Sibener, Amy F T Arnsten and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James Newton BrandtLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Alessandra Bonito-OlivaLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Navid PaknejadLaboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, 10065, USA.
Celine ChenLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
John FakLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Andrew LuskinLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Genelle RankinLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Miriam KiryloLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Leslie J SibenerLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.
Amy F T ArnstenDepartment of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 USA.
Vanessa RutaLaboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, 10065, USA.ORCID 0000-0002-4963-2768
Priya RajasethupathyLaboratory of Neural Dynamics & Cognition, The Rockefeller University, New York, NY 10065, USA.

Funding

Weill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6M
Chronic and acute molecular programs enabling working memoryR01MH133201 · NIMH · ROCKEFELLER UNIVERSITY · PI RAJASETHUPATHY, PRIYA · 2024 to 2025
$848k
NIGMS NIH HHS T32 GM152349NIMH NIH HHS R01 MH133201
6 · The paper itself

Abstract

Working memory capacity is poorly understood. The ability to control and extend working memory time-scales provides the potential to alleviate cognitive decline in disease and aging. Through an unbiased genetic search, we previously identified a thalamic orphan receptor Gpr12 as a potent enhancer of working memory, however its activation mechanism remains poorly understood. Here, we describe the CryoEM structure of Gpr12, revealing a lipidic regulatory site enabling an activated signaling state. By surveying the native lipidic environment in mouse thalamus we identified a class of 20 carbon:4 double bond fatty acid eicosanoids as potential ligands. Cell-based assays confirmed that the endogenous cannabinoid anandamide (AEA), but not other closely related family members or derivatives, robustly activates Gpr12.

Identifiers

PMID42818673
PMCPMC13622573

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.