Evidence map›Paper›PMID 42818681›Full record

ArticlebioRxiv : the preprint server for biology2026

A positively selected microRNA controls a reversible aging program in striated muscle.

Melissa A Boldridge, Lei Xu, Xiaoyin Wang, Michael Stirm, Gracia Bonilla, Chi Zhu, Justin Y Lee, Rachelle L Stark, Sneha Damal Villivalam, Marianne Bengtson Løvendorf and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Melissa A BoldridgeDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Lei XuDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Xiaoyin WangDivision of Cardiology, University of California, San Francisco, San Francisco, California, USA.
Michael StirmChair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.
Gracia BonillaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Chi ZhuDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Justin Y LeeDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Rachelle L StarkDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Sneha Damal VillivalamDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Marianne Bengtson LøvendorfLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Andreas PetriCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
Alexandre WagschalVertex Pharmaceuticals, Boston, Massachusetts.
Caslin GilroyDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Federico GonzalezDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Lei CaiSaha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Peter I HeckerSaha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Mogens VybergCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
Rahul AlmeidaDivision of Cardiology, University of California, San Francisco, San Francisco, California, USA.
Chaitanya PunnatiDivision of Cardiology, University of California, San Francisco, San Francisco, California, USA.
Christopher JinDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Theresia M SchnurrDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Dominique O RiddellComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.
John C W HildyardComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.
Bachuki ShashikadzeLaboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany.
Andreas LangeChair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.
Nikolai KlymiukCenter for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany.
Thomas FröhlichLaboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany.
Sakari KauppinenCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
Richard J PiercyComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.
Joshua W KnowlesDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Alexander FayDepartment of Neurology, Division of Child Neurology, UCSF School of Medicine, San Francisco, CA, USA.
Sona KangDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.
Ryan E TemelSaha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Eckhard WolfChair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.
Matthew L SpringerDivision of Cardiology, University of California, San Francisco, San Francisco, California, USA.
Anders M NäärDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, California, USA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
PROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ST.HELEN, GIDEON · 2018 to 2022
$20.4M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Epigenetic regulation of adipose development and remodelingR01DK116008 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Sona Kang · 2018 to 2026
$3.6M
Characterization of novel insulin resistance genes by gene editing, high-throughput phenotyping and in vivo studiesR01DK120565 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2019 to 2023
$3.2M
Mechanisms of NAT2 Regulation of Insulin Resistance and Mitochondrial DysfunctionR01DK116750 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2019 to 2023
$2.4M
Beyond GWAS of insulin resistance: An integrated approach to translate genetic association to functionR01DK106236 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2016 to 2020
$2.4M
Molecular Mechanisms of Insulin Resistance Associated LociR01DK137889 · NIDDK · STANFORD UNIVERSITY · PI Joshua Wiley Knowles · 2024 to 2026
$1.8M
A Thrifty MicroRNA in Insulin Resistance and Type 2 DiabetesR01DK114277 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAAR, ANDERS M · 2017 to 2019
$1.1M
Regulation of Insulin Sensitivity by a Novel AdipokineR01DK147451 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Sona Kang · 2026 to 2026
$794k
Therapeutic targeting of miR-128-1 in Duchenne muscular dystrophyR56NS128721 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KANG, SONA, NAAR, ANDERS M · 2022 to 2022
$401k
NHLBI NIH HHS U54 HL147127NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK106236NIDDK NIH HHS R01 DK114277NIDDK NIH HHS R01 DK116008NIDDK NIH HHS R01 DK116750NIDDK NIH HHS R01 DK120565NIDDK NIH HHS R01 DK137889NIDDK NIH HHS R01 DK147451NINDS NIH HHS R56 NS128721Wellcome Trust
6 · The paper itself

Abstract

Aging is the primary risk factor for most chronic diseases and is characterized in striated muscle by progressive functional decline, mitochondrial dysfunction, and chronic inflammation. The miR-128-1 locus resides within a positively selected haplotype on chromosome 2q21.3 associated with variation in grip strength, pulmonary function, and cardiometabolic traits in humans. Here, we show that antisense oligonucleotide-mediated inhibition of miR-128-3p restores muscle mass and function in aged mice, improves cardiac function while limiting adverse remodeling following myocardial infarction, and ameliorates skeletal and cardiac muscle pathology in mouse and pig models of Duchenne muscular dystrophy. Across these contexts, miR-128-3p inhibition induces a conserved transcriptional response characterized by activation of mitochondrial programs and suppression of inflammatory and fibrotic signaling, resembling the effects of established longevity interventions. These findings identify miR-128-3p as a regulator of a conserved aging-associated program and establish its inhibition as a strategy to restore tissue function across aging-related muscle pathologies.

Indexed as

agingantisense oligonucleotideschronic inflammationDuchenne muscular dystrophylongevity interventionsmiR-128–3pmitochondrial dysfunctionmyocardial infarctionsarcopeniastriated muscle

Identifiers

PMID42818681
PMCPMC13622596

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.