Evidence map›Paper›PMID 42818784›Full record

ArticleFrontiers in immunology2026

Integrative transcriptomic and single-cell analysis reveals a convergent cholangiocyte-associated host inflammatory program in biliary atresia and SARS-CoV-2-associated hepatobiliary injury.

Yujuan Wa, Rong Guan, Zhanwei Du, Rouchen Lin, Shiyu Cui, Jianglei Guang, Lidan Xu, Wei Ji, Qian Yang, Qingbo Cui and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yujuan Wa *Department of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Rong Guan *Department of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Zhanwei DuDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Rouchen LinDepartment of Microbiology, Harbin Medical University, Harbin, China.
Shiyu CuiDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jianglei GuangDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Lidan XuDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wei JiDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Qian YangDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Qingbo CuiDepartment of Pediatric Surgery, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, China.
Hao WangDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenjing SunDepartment of Medical Genetics, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2-associated hepatobiliary injury and biliary atresia (BA) differ markedly in etiology and biological context, but both involve injury to the biliary epithelial compartment. Here, we performed integrative transcriptomic and single-cell analyses to investigate whether these distinct hepatobiliary injury contexts converge on a shared cholangiocyte-associated inflammatory host-response program. Bulk transcriptomic datasets from SARS-CoV-2-infected human liver organoids and BA liver tissues were integrated to identify shared transcriptional alterations, followed by functional enrichment, protein-protein interaction, regulatory network, drug-gene interaction, and molecular docking analyses. Single-nucleus and single-cell datasets were used to determine the cellular localization of the shared program, and key findings were further assessed in BA liver tissues and cultured human cholangiocytes exposed to poly(I:C). We identified an expanded exploratory set of 164 shared genes and a stringent

Indexed as

Biliary AtresiaCOVID-19SARS-CoV-2TranscriptomeBile DuctsEpithelial CellsGene Expression ProfilingHumansInflammationLiverSingle-Cell Analysisbiliary atresiacholangiocytehost inflammatory responseintegrative transcriptomicspediatric cholangiopathyperinatal infectionSARS-CoV-2single-cell transcriptomics

Identifiers

PMID42818784
PMCPMC13624073

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.