Evidence map›Paper›PMID 42818922›Full record

ArticleResearch square2026

Selective vulnerability and resilience of thalamic neuronal populations in Frontotemporal Dementia.

Amber E Trujillo, Mira Sohn, Magdalena J Macias, Martyna M Grochowska, John Joyce, Isabelle Leber, Dann Huh, Anton Schulmann, Francis J McMahon, Kendall Van Keuren-Jensen and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amber E TrujilloMolecular Pathology Unit, Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Mira SohnMolecular Pathology Unit, Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0000-1929-9856
Magdalena J MaciasMolecular Pathology Unit, Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Martyna M GrochowskaMolecular Pathology Unit, Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
John JoyceResearch, Biogen Inc, Cambridge, MA 02142, USA.
Isabelle LeberParis Brain Institute (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne University, APHP-Hôpital Pitié-Salpêtrière, Paris 75013, France.
Dann HuhResearch, Biogen Inc, Cambridge, MA 02142, USA.
Anton SchulmannDepartment of Psychiatry, Columbia University; New York State Psychiatric Institute, New York, NY 10032, USA.
Francis J McMahonHuman Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9469-305X
Kendall Van Keuren-JensenBioinnovation and Genome Sciences Division, Translational Genomics Research Institute (TGen), City of Hope, Phoenix, AZ 85004, USA.
Morwena LatoucheEcole Pratique des Hautes Etudes, PSL Research University, 75014 Paris, France.
Elise MarsanMolecular Pathology Unit, Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-1975-290X

Funding

Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2M
ALZHEIMERS RESEARCH PROJECT: Dissecting Common and Distinct Disease Signatures Across AD/ADRD Postmortem Brain Samples Through Single-cell and Spatial ProfilingZIAAG000554 · NIA · NATIONAL INSTITUTE ON AGING · PI MARSAN, ELISE · 2025 to 2025
$2.2M
Intramural NIH HHS ZIA AG000554Intramural NIH HHS ZIA MH002810
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) caused by progranulin (

Identifiers

PMID42818922
PMCPMC13622835

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.