Evidence map›Paper›PMID 42818943›Full record

ArticleResearch square2026

Quantitative dissection of the metastatic cascade at single colony resolution.

Chris Roberts, Andy Xu, Xiangwei Fang, Adrienne Visani, Chien-Wei Peng, Xulei Qin, Irenaeus C C Chan, Madeline Dunterman, David A Giles, Yaoxuan You and 9 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chris RobertsTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
Andy XuTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2428-3266
Xiangwei FangDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0004-8061-7680
Adrienne VisaniDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5379-3687
Chien-Wei PengDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Xulei QinDepartment of Surgery, Stanford University, Stanford, CA, USA.
Irenaeus C C ChanCancer Biology Graduate Program, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0009-0004-3250-9626
Madeline DuntermanTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
David A GilesTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2745-4374
Yaoxuan YouTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
Isabella GuppyTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0009-5809-5376
Zhang YangTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
Timothy WoodiwissTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
Albert H KimTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1751-8493
Alexander H SteghTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.
Guolan LuDepartment of Urology, Stanford University, CA, USA.
Feng ChenDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-2307-7954
Li DingDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-1517-2975
Rui TangTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6950-9580

Funding

WU-SN-TMC Data Analysis CoreU54AG075934 · NIA · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2021 to 2026
$8.0M
Human Prostate Tumor Atlas CenterU01CA294532 · NCI · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2024 to 2026
$5.3M
Impact of cancer predisposition on oncogenic process, microenvironment, and treatmentR01CA260112 · NCI · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2022 to 2026
$2.4M
Dissecting reciprocal interactions between cancer cells and endothelial cells in SCLC liver metastasis.R00CA256039 · NCI · WASHINGTON UNIVERSITY · PI Rui Tang · 2024 to 2026
$743k
NCI NIH HHS R00 CA256039NCI NIH HHS R01 CA260112NCI NIH HHS U01 CA294532NIA NIH HHS U54 AG075934
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related deaths. However, the core determinants and mechanistic principles underlying the metastatic cascade remain elusive. Small cell lung cancer (SCLC) is a highly aggressive malignancy with exceptional metastatic potential and limited therapeutic options. Here, we present Metastasis Originated Barcode Sequencing (MOBA-seq), a high-throughput

Identifiers

PMID42818943
PMCPMC13622843

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.