ArticleJACS Au2026
Reactivity-Guided Selective Covalent Targeting of mtDNA over nDNA by an NHC-Rhenium Complex Triggers Bioenergetic Collapse in Cancer Cells.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Mitochondrial DNA (mtDNA) has emerged as a promising target for the development of next-generation chemotherapeutics, as its damage can disrupt key processes that drive cancer progression and resistance to nuclear DNA (nDNA)-targeting drugs. However, achieving selective and direct targeting of mtDNA remains a significant challenge due to its nucleobase similarity to nDNA and necessitates mitochondria-directed delivery strategies. This study reports the identification of a novel N-heterocyclic carbene (NHC) rhenium (Re) complex
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