Evidence map›Paper›PMID 42819442›Full record

ArticleFrontiers in neurology2026

Adult Epstein-Barr virus encephalitis: a retrospective case report series with metagenomic next-generation sequencing-based diagnosis.

Yinghui Li, Zhejun Yu, Meili Shen, Shaobo Cui, Xinjing Yang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yinghui Li *Department of Emergency, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Zhejun Yu *Department of Intensive Care Unit, The First Affiliated Hospital of Soochow University, Suzhou, China.
Meili ShenDepartment of Medecine, Dinfectome Inc., Nanjing, China.
Shaobo CuiDepartment of Critical Care Medicine, Jincheng General Hospital, Jincheng, China.
Xinjing YangDepartment of Intensive Care Unit, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: EBV encephalitis is uncommon in adults, and its diagnosis and management remain challenging, particularly in patients with underlying medical conditions. Methods: We retrospectively analyzed seven adult patients with EBV encephalitis confirmed through cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) between December 2021 and January 2024. Results: Six patients (86%) were female, with a median age of 59 years. Five patients had significant underlying conditions, including malignancies ( Conclusion: MRI is the preferred imaging modality for suspected encephalitis, and CSF-mNGS is an essential pathogen detection assay. Underlying conditions such as malignancies and HLH are associated with poor clinical outcomes.

Indexed as

Encephalitis, ViralEpstein-Barr Virus InfectionsAdultAgedAntiviral AgentsFemaleHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansMagnetic Resonance ImagingMaleMetagenomicsMiddle AgedRetrospective StudiesAntiviral Agentsclinical featuresencephalitisEpstein–Barr virusmetagenomic next-generation sequencingprognosistreatment

Identifiers

PMID42819442
PMCPMC13624100

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.