ArticleResearch in heart yield and translational medicine2025
Association between Hypertension with and without Left Ventricular Hypertrophy and the Expression of a Panel of microRNAs in an Iranian Population.
Article in Research in heart yield and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Highlights: Left ventricular hypertrophy (LVH) is a critical independent predictor of cardiovascular mortality and is strongly associated with hypertension.Given the diagnostic potential of microRNAs (miRNAs) as biomarkers in hypertension, this study aimed to investigate their expression profiles.The findings underscore the significant involvement of miR-222 and miR-155 in hypertension and LVH pathogenesis. Introduction: Given the established role of microRNAs (miRNAs) in hypertension (HTN), this study aimed to analyze the expression of a defined miRNA panel in hypertensive individuals, both with and without left ventricular hypertrophy (LVH), compared with normotensive controls within an Iranian population. Methods: We conducted a cross-sectional study with case-control sampling, comprising three study groups: controls, HTN, and HTN+LVH. Through an extensive literature review, we selected a panel of eight miRNAs (miR-1, miR-21, miR-29a, miR-29b, miR-133, miR-155, miR-221, and miR-222) for analysis using real-time PCR. Gene expression data were analyzed through a general linear model implemented in R programming. Results: The study analyzed 100 total samples. We used miR-29a and miR-133 as endogenous controls for calculations. Analysis revealed no significant association between miR-29b or miR-221 expression and the study groups (P>0.2 for both). Additionally, miR-1 demonstrated downregulation in both hypertensive groups (P<0.05), although this effect lost significance after adjusting for potential confounders (P=0.05-0.2). The HTN+LVH group showed significant downregulation of miR-21 (P<0.05). The duration of HTN diagnosis correlated with the upregulated expression of both miR-155 and miR-222. The strongest association emerged for miR-222, with the study groups explaining 25.7% of its variation (the highest R Conclusions: HTN without LVH might be associated with the downregulation of miR-1 and miR-155 and the upregulation of miR-222. HTN, along with LVH, might be associated with the downregulation of miR-1 and miR-21 and the upregulation of miR-222. Increasing years of experiencing HTN were correlated with the upregulation of miR-155 and miR-222. The largest effect size was for miR-222.
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