Evidence map›Paper›PMID 42819782›Full record

ReviewFrontiers in cellular neuroscience2026

Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.

Mengjie Zhang, Xueying Huang, Lin Yao, Wenqing Wu

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengjie ZhangInnovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xueying HuangDepartment of Pain Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Lin YaoInnovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wenqing WuDepartment of Pain Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain endothelial cells (BECs) are specialized components of the neurovascular unit that couple circulating signals to cerebral blood flow regulation, blood-brain barrier (BBB) function, and selective molecular transport. This narrative review evaluates the correlation of these endothelial functions with psychiatric disorders, including depression and schizophrenia, distinguishing established vascular physiology from disease-specific evidence. In neurovascular coupling, the functions of capillary Kir2.1/phosphatidylinositol 4,5-bisphosphate and ATP-sensitive K

Indexed as

brain endotheliumCBFdepressionmental disordersneurovascular couplingpsychiatric disorders

Identifiers

PMID42819782
PMCPMC13624901

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.