Evidence map›Paper›PMID 42820083›Full record

ArticlePrecision chemistry2026

Precise Temperature-Gradient Regulated Structure-Activity Relationship of PCN-224 as Bifunctional Nanocarriers.

Lejie Tian, Huidan Xue, Michael Gradzielski, Li Shang, Shuanhong Ma, Peiwei Gong, Long Wang, Jianxi Liu, Weimin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Precision chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lejie TianState Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Huidan XueSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID https://orcid.org/0000-0001-5429-7477
Michael GradzielskiStranski-Laboratory for Physical and Theoretical Chemistry, Institute of Chemistry, Technische University Berlin, Berlin 10623, Germany.ORCID https://orcid.org/0000-0002-7262-7115
Li ShangState Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.ORCID https://orcid.org/0000-0003-1575-1934
Shuanhong MaState Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.ORCID https://orcid.org/0000-0002-2144-4378
Peiwei GongKey Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, Key Laboratory of Advanced Lubrication and Energy Materials of Jining City, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong China.
Long WangState Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Jianxi LiuState Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.ORCID https://orcid.org/0000-0002-6394-600X
Weimin LiuState Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic frameworks (MOFs) demonstrate considerable potential for biomedical applications. Due to their high porosity and photoactive porphyrin ligands, PCN-224 is considered an ideal drug delivery nanocarrier. However, the synthesis strategy for tailoring the application of PCN-224 in complex pathological diseases remains unclear. In this study, we investigated the structure-activity relationship of PCN-224 nanoparticles as bifunctional nanocarriers for osteoarthritis (OA) treatment under a precisely controlled temperature gradient. By tuning the temperatures, a series of PCN-224 nanoparticles with adjustable sizes were synthesized and their morphologies transitioned from a spindle-shaped to a spherical-shaped structure. The photoluminescence intensity of PCN-224 nanoparticles decreased as the synthesis temperatures increased. Using PCN-224 nanoparticles as aqueous lubricating additives, both the friction coefficient and wear volume were significantly reduced. Among the MOFs, PCN-224 (synthesized at 105 °C) exhibited excellent antifriction performances and acid-responsive drug release properties, demonstrating their promise as bifunctional OA treatment nanocarriers. Our work enhanced the understanding of the relationships between PCN-224 synthesis conditions and its physicochemical properties relationships, expanding their potential for multifunctional biomedical applications.

Indexed as

Aqueous lubricationDrug releaseMOFsPhotoluminescencePorphyrin

Identifiers

PMID42820083
PMCPMC13625909

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.