SynthesisMolecular neurobiology2026
MicroRNAs Regulation of Axon Sprouting in Peripheral Nerve Regeneration: A Systematic Review.
Synthesis in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
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Abstract
Peripheral nerve injuries frequently result in long-term motor and sensory deficits, chronic pain, and incomplete functional recovery despite advances in surgical and rehabilitative approaches. MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression that influence axonal sprouting and peripheral nerve regeneration. This systematic review synthesizes current evidence on the roles of key miRNAs, particularly miR-21, miR-133b, miR-124, and miR-30b, in modulating critical signaling pathways including PI3K/Akt/mTOR and Rho/ROCK. These miRNAs contribute to axonal outgrowth, Schwann cell responses, and the resolution of inflammation. Preclinical studies demonstrate that miRNA-loaded exosomes and other delivery platforms can enhance neurite outgrowth and functional recovery in models of sciatic nerve injury. Various delivery systems, including viral vectors, polymeric nanoparticles, hydrogels, and engineered exosomes, have been investigated for targeted miRNA administration. Nevertheless, challenges related to the complexity of miRNA regulatory networks, efficient and specific delivery, and scalable production remain significant barriers to clinical translation. Overall, miRNA-based strategies represent a promising avenue for improving outcomes after peripheral nerve injury, provided that current limitations in delivery and specificity can be effectively addressed.
Indexed as
Identifiers
42821019What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.