ArticleNature communications2026
Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
Skeletal muscle hypertrophy is a hallmark of resistance training that improves health and longevity. However, despite physiological differences between sexes and fiber types, the underlying proteome changes with resistance training have not been studied in a sex- and fiber type-specific manner. Herein, we show sex- and fiber type-specific remodeling of the human skeletal muscle proteome following 8 weeks of resistance training. Type II fibers exhibited much greater adaptations across both sexes, whereas the main sex difference was a greater remodeling of intermediate filaments in females. Of proteins that were specifically upregulated in type II fibers, overexpression of CSRP3 increased muscle mass in mice, indicating a role of fiber type-specific upregulation of CSRP3 in muscle hypertrophy. In addition, abundance of proteins involved in translation correlated with fiber hypertrophy and differed between sexes and fiber types. These findings demonstrate sex- and fiber type differences in muscle physiology and their contributions to resistance training-induced adaptions and implicate involvement of CSRP3 in resistance training-induced muscle hypertrophy.
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