Evidence map›Paper›PMID 42823536›Full record

ArticleNature metabolism2026

Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial.

Mijra Koning, Artemiy Kovynev, Marcos F Fondevila, Eliza J M Ruhe, Michiel C Mommersteeg, Christian Ramakers, Barbara A Hutten, Bart Verwer, Marije Vlug, Teaco Kuiper and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Mijra KoningDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Artemiy KovynevTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Marcos F FondevilaDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5099-3421
Eliza J M RuheDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Michiel C MommersteegDepartment of Gastroenterology, Haga Hospital, Den Haag, the Netherlands.
Christian RamakersDepartment of Clinical Chemistry, Erasmus University Medical Centers, Rotterdam, the Netherlands.
Barbara A HuttenAmsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9243-0037
Bart VerwerDepartment of Gastroenterology, Spaarne Gasthuis Hoofddorp, Hoofddorp, the Netherlands.
Marije VlugDepartment of Gastroenterology, Dijklander Hospital, Hoorn, the Netherlands.
Teaco KuiperDepartment of Gastroenterology, Amstelland Hospital, Amstelveen, the Netherlands.
Maarten van den BergDepartment of Gastroenterology, Haga Hospital, Den Haag, the Netherlands.
Anne VriezeDepartment of Gastroenterology, Flevo Hospital, Almere, the Netherlands.
Maurice BizinoDepartment of Internal Medicine, Groene Hart Hospital, Gouda, the Netherlands.
Annewieke van den BeldDepartment of Internal Medicine, Groene Hart Hospital, Gouda, the Netherlands.
Luuk BerkDepartment of Gastroenterology, Fransiscus Hospital, Rotterdam, the Netherlands.
Thomas BoerlageDepartment of Gastroenterology, Groene Hart Hospital, Gouda, the Netherlands.
Quinten J J AugustijnDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Willem Pieter BrouwerDepartment of Gastroenterology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8713-1481
Weena J ChenDepartment of Internal Medicine, Amstelland Hospital, Amstelveen, the Netherlands.
Djuna CahenDepartment of Gastroenterology, Amstelland Hospital, Amstelveen, the Netherlands.
Robert VerdonkDepartment of Gastroenterology, St. Antonius Hospital, Nieuwegein, the Netherlands.
Wouter J de JongeDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Sandjai RamsoekhDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Michail DoukasDepartment of Pathology, Erasmus University Medical Centers, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-8611-840X
Sanne M M VermorgenDepartment of Pathology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Joanne VerheijDepartment of Pathology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Ulrich BeuersDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-5114-7799
R B TakkenbergDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2179-1385
Jacques J G BergmanDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Geert R A M D'HaensDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2784-4046
Joost P H DrenthDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Tamar TchkoniaCenter for Advanced Gerotherapeutics, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Bernd SchnablDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6281-825X
James L KirklandCenter for Advanced Gerotherapeutics, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Abraham S MeijnikmanDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands. a.s.meijnikman@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-6015-4656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence plays an important role in hepatic inflammation and fibrosis

Identifiers

PMID42823536

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.