ReviewEarly intervention in psychiatry2026
Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review.
Review in Early intervention in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPsychiatric biomarker research has traditionally been organized around diagnostic categories, but clinical heterogeneity, comorbidity and shared biological mechanisms across psychiatric conditions have increased interest in transdiagnostic approaches. These approaches may be especially relevant for early recognition, stratification and intervention planning. Despite this growing interest, the concept of the transdiagnostic biomarker remains unclear. This conceptual review aimed to clarify how transdiagnostic biomarkers of psychopathology are represented in psychiatric research.
methodsSystematically identified empirical literature and concept explication were used to examine biomarker modalities, indexed psychopathology-related constructs, transdiagnostic framing and conceptual boundary issues across studies.
resultsTransdiagnostic biomarker research was found to encompass several approaches, including diagnosis-spanning comparisons, symptom-based models, subgroup-based approaches, cross-domain extensions beyond traditional psychiatric categories and research aligned with alternative frameworks such as the Research Domain Criteria or the Hierarchical Taxonomy of Psychopathology. A conceptual framework is proposed comprising three linked elements: the measurable indicator, the psychopathology-related construct and the transdiagnostic scope of that construct. Within this framework, a transdiagnostic biomarker is defined as a measurable biological or biobehavioural indicator of a psychopathology-related construct that spans multiple diagnostic categories or extends beyond them.
conclusionGreater conceptual clarity of transdiagnostic biomarkers may strengthen psychiatric biomarker discovery by improving construct alignment and supporting their use in biomarker-informed stratification, early intervention, treatment selection, prognosis and precision psychiatry.
Indexed as
Identifiers
42823648What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.